However, as gallbladder disease is not an issue with sodium-glucose co-transporter-2 (SGLT-2) inhibitors (with similar weight loss) (89), and gallbladder events also occurred in GLP-1RA-treated patients well after weight reduction (90), other mechanisms are possibly in play
And, it decreases glucagon secretion in the body
While tirzepatide does not require dose adjustment for renal impairment, gastrointestinal side effects (nausea, vomiting, diarrhea) could potentially lead to dehydration and acute kidney injury, particularly in patients taking renally excreted beta blockers like atenolol
Keshavarzian A, Holmes EW, Patel M, Iber F, Fields JZ, Pethkar S
At week 13, significant, dose-dependent reductions in HbA 1c (the primary endpoint) were reported [10]
The number of sessions required can vary