Combining GLP-1 receptor agonists with DPP-4 inhibitors is generally not recommended due to limited additive benefit
Lifestyle modifications should be the first-line approach and include: Eating smaller, more frequent meals rather than large portions that overwhelm the already-slowed digestive system Avoiding eating within 2-3 hours of bedtime to allow adequate time for gastric emptying before lying down Elevating the head of the bed by 6-8 inches using blocks or a wedge pillow to reduce nocturnal reflux Identifying and avoiding trigger foods such as caffeine, alcohol, chocolate, spicy foods, citrus, and high-fat meals Maintaining an upright posture for at least 2-3 hours after meals Wearing loose-fitting clothing that doesn't compress the abdomen Pharmacological management may be appropriate for patients with persistent symptoms despite lifestyle modifications
Acknowledgements We gratefully acknowledge the resources provided by the Institute for Precision Health and participating patients from the UCLA ATLAS Community Health Initiative ( The UCLA ATLAS Community Health Initiative in collaboration with UCLA ATLAS Precision Health Biobank is a program of the Institute for Precision Health, which directs and supports the biobanking and genotyping of biospecimen samples from participating patients from UCLA in collaboration with the David Geffen School of Medicine, UCLA Clinical and Translational Science Institute and UCLA Health
Lixisenatide reduces amyloid plaques, neurofibrillary tangles and neuroinflammation in an APP/PS1/tau mouse model of alzheimers disease
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Husain KH, et al
