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ALT, glutamic-pyruvic transaminase

The biomarker approach requires analytical evaluation of (poly)phenol metabolites in biofluids to essentially reverse-trace a (poly)phenol from its end-stage metabolites towards its precursor and subsequently to its sources in food (Reference Scalbert, Brennan and Manach19)

Future studies should investigate the role of the two mechanisms, as well as assess the duration of therapeutic efficacy and an optimal treatment dosage

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing sp1 glycosylation

Figure 2 was created with BioRender.com

Concentration can often reduce for maintenance versus active improvement