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A potential treatment regimen might include: (1) a short course of immunomodulation (e.g., with a biologic drug) to suppress the active autoimmune response, followed by (2) transplantation of stem cell-derived beta cells, potentially gene-edited and engineered to evade the immune system, possibly combined with (3) Treg adjuvant therapy to maintain long-term tolerance [133]
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CJC-1295 alone, without an accompanying secretagogue, amplifies pituitary somatotroph sensitivity but does not strongly trigger the GH-release pulse itself
Here the Synaptic Tagging and Capture hypothesis (STC) (Frey and Morris, 1997
Zhang, S
Science 351 , 12141218 (2016)
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