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The availability of epinephrine nasal spray may reduce barriers to rapid treatment of anaphylaxis. Neffys approval is based on four studies in 175 healthy adults, without anaphylaxis, that measured epinephrine concentrations in the blood following administration of the nasal spray or approved epinephrine injection products

Saied NM, Hassan WA (2014) Long-term exposure to xenoestrogens alters some brain monoamines and both serum thyroid hormones and cortisol levels in adult male rats

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Starting with a lower titration is common in research protocols

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Additionally, pups of choline-supplemented dams exhibited lymphocytes that produced lower IL-6 and IFN- following concanavalin A stimulation, compared to those from the 100% free choline group (87)