Instead of continuing full therapeutic doses, the goal of maintenance is to: Keep appetite and cravings stable Support metabolic balance Prevent rapid rebound weight gain Allow your body to adjust gradually Why GLP-1 Maintenance Matters GLP-1 medications work at multiple levels: blood sugar regulation, appetite signaling, digestion speed, insulin release, and even reward-based eating patterns
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Exosome formation increased after GPX4 inhibition, which contained prominin and TSG101, as well as ferritin, while blocking the export of exosomes resulted in the accumulation of iron, indicating that in the state of cellular oxidative stress, prominin 2 can promote the formation of iron-containing exosomes and transport intracellular iron to the extracellular space, thereby enhancing cell resistance to ferroptosis [75]
Cost vs benefit: Given modest effect, the return may be limited compared to healthy habits (diet, sleep, sun protection)
Additionally, developing novel efficacy endpoints beyond conventional CAP, such as evaluating the specific modulation of hepatic triglyceride compositionparticularly the proportion of lipotoxic saturated fatty acidsmay more directly elucidate the mechanisms underlying its hepatoprotective effects
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