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Limitations and Research Status While preclinical data is extensive, large-scale human clinical trials are limited

Take photos to track progresssometimes gradual changes are hard to notice day-to-day but become obvious when compared over weeks

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These complications tend to occur when the administering doctor does not properly carry out the treatment

Those most at risk include vegans and vegetarians, people with digestive conditions such as Crohn's disease, coeliac disease or IBS, those taking long-term metformin or proton pump inhibitors, older adults whose ability to absorb B12 through the gut declines naturally with age, those with pernicious anaemia, and anyone with a history of chronic alcohol use

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