Who should not take GLP-1s GLP-1s in all forms are unsuitable for people who: are pregnant or breastfeeding do not meet the eligibility criteria have a family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2) Medical Perspective Patients with needle phobia, a preference for pill-based routines, or good adherence to oral administration guidelines may be better suited to oral GLP-1 formulations like semaglutide (Rybelsus, Wegovy), which can enhance treatment acceptance and potentially offer strong glycemic or weight control
Also, a clinical study suggests that taking berberine in combination with amlodipine can lower systolic and diastolic blood pressure when compared with amlodipine alone
The mechanism of action is unclear but may involve multiple pathways
Each escalation step can temporarily increase side effects
Because it targets GLP-1, GIP, and glucagon pathways, side effects and monitoring needs may be more complex than single-pathway medications
no regulatory body Health Canada, the FDA, the EMA, the TGA, or any equivalent has approved the compound as a drug for human or veterinary use