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Once inside the cell, cystine is reduced to cysteine by the enzyme thioredoxin reductase 1 (TXNRD1) ( Figure 1 ) ( C - , which operates as a heterodimeric complex of SLC7A11 and SLC3A2, enables the exchange of cystine and glutamate across the plasma membrane ( Figure 1 ) ( Ferroptosis inhibitory protein 1 (FSP1) serves as an important antioxidant involved in the mechanism of ferroptosis ( Figure 1 ) ( CoQ10 can be synthesized by the mevalonate (MVA) pathway using acetyl coenzyme A ( Tetrahydrobiopterin (BH4) possesses robust antioxidant properties, enabling it to directly curb lipid peroxidation ( Figure 1 )

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Since the platform consolidates only de-identified data summaries and counts, TriNetX has been granted an informed consent waiver by the Western Institutional Review Board 42

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10.1371/journal.pmed.1003198 7 DongY