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Its main active ingredient, total dajizin triterpenes, reduces the expression of ACSL4 in the rat model of RA, increases the expression of glutathione and GPX4, and upregulates Kelch-like ECH-associated protein 1 and HO-1 in the Nrf2/HO-1/GPX4 pathway, indicating that total dajizin triterpenes can inhibit cell aberrant ferroptosis by suppressing lipid peroxidation and thus exert therapeutic anti-RA effects [168]

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10.2337/db09-0638 125 ToyoshimaY.GavrilovaO.YakarS.JouW.PackS.AsgharZ.et al

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Practically, distinguishing signalling from damage relies on complementary readouts: signalling proxies include reversible cysteine oxidation captured by redox proteomics, the redox state of peroxiredoxins, compartment-targeted H 2 O 2 reporters and phospho-signatures downstream of redox-sensitive kinases

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