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When GLP-1 released from the gut latches on to the vagus nerve, the nerve sends signals up the brain stem to the nucleus tractus solitarius (NTS), a bundle of sensory neurons deep in the brain

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How the #incretin effect is impaired by #hyperglycemia in the brain and elsewhere through #glycolyticoverload

Phosphorylated glycogen phosphorylase clips glucose units from glycogen as glucose 1-phosphate

Kwong AJ, et al

By targeting key metabolic pathwaysincluding weight reduction, insulin resistance, and chronic inflammationsemaglutide has the potential to modify the natural history of liver disease in carefully selected patients