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Our studies on rod Igf-1r / mice showed decreased levels of myo -inositol, which is an important molecule in PI synthesis [34]

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Taking a different approach, we then engineered the fusion molecule to create steric hindrance around the peptide and block its degradation by proteases either by creating an N-linked glycosylation site at position 25 of the GLP-1 analogue peptide (Ab#2_GLP1 W25N/V27S) or by introducing a disulphide bridge between the exendin-4 peptide and the linker (Ab#2_DSB#1)

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doi: 10.1111/nmo.13260 155 OMahonySMClarkeGBorreYEDinanTGCryanJF

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