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Previously, we have reported that deletion of Dpp4 from the Tie2 + ECs ( Dpp4 EC/ ) of high-fatfed mice results in increased systemic concentrations of GLP-1 and improved glucose excursion but does not affect HGP (38)
GLP-1 and GIP options may include Tirzepatide, Semaglutide, Mounjaro, Zepbound, Wegovy, and Ozempic when clinically appropriate
Here's what the research and anecdotal evidence suggest for common use cases
Their approved indications are limited to type 2 diabetes mellitus and chronic weight management for specific agents at designated doses
The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats