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Without adequate protein intake and resistance training, there is a greater risk of losing muscle mass as you lose weight

The clinical significance of elevations in lipase or amylase with SAXENDA is unknown in the absence of other signs and symptoms of pancreatitis [see Warnings and Precautions (5.2)]

It is also likely an indirect effect of weight loss

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and MOTS-ca mitochondrial-derived peptide that enhances metabolic efficiency, insulin sensitivity, and cellular energy production

The drug is metabolized via proteolytic cleavage and beta-oxidation of the fatty acid side chain, with metabolites excreted primarily in urine and feces