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In a multicenter, double-blind, randomized, placebo-controlled, event-driven superiority trial, designed to evaluate the efficacy and safety of 2.4 mg semaglutide in patients 45 years old with preexisting cardiovascular disease and a BMI 27 kg/m 2 but no history of diabetes, the trial randomly assigned 17,604 patients to receive semaglutide or placebo to determine whether semaglutide is superior to placebo in reducing cardiovascular events

abandon if no improvement after 3 months (return to standard dosage)

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Salicylic acid is a melanin inhibitor and an acne-fighting ingredient that evens out the skin tone by gently exfoliating it

10.1016/j.jnutbio.2020.108573 28 ItohK.ChibaT.TakahashiS.IshiiT.IgarashiK.KatohY.et al (1997)