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Neuroprotection of UA may be mediated by the Akt/GSK3 signaling pathway [136]

Key points Incretins have an important role in glucose homeostasis, regulation of appetite, energy expenditure and immunity

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Protecting lean mass during cagrilintide use Until definitive data emerges, established principles for lean mass preservation apply: Resistance training at least 2 to 3 sessions per week provides the strongest stimulus for muscle preservation Protein intake of 0.7 to 1.0 grams per pound of body weight daily, even when appetite is suppressed Adequate total calories avoiding deficits greater than 500 to 750 calories below maintenance Creatine supplementation may provide additional support for muscle maintenance during caloric restriction For researchers specifically interested in maintaining muscle while losing fat, our guide on the best peptides for muscle growth covers complementary approaches

doi:10.1345/aph.1A122

Aging Cell 12 , 148155, (2013)