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Just some of the fascinating insights that rocked the GLP-1 incretin world this week-a glimpse of top line data for AMG-133 the GIPR Antagonist-GLP1R Agonist antibody

Compounded semaglutide is not an FDA approved finished drug

and finally employs an endosomal enzyme, cathepsin L (CTSL) for fusogenic release of its viral genome

Novo Nordisk (NVO): In 2023, Novo Nordisk announced the results from its SELECT trial that showed that semaglutide was associated with a 20% decreased risk of major adverse cardiac events comprised of cardiovascular death, nonfatal myocardial infarction (MI), and stroke compared with placebo in patients with overweight or obesity and established CVD but without diabetes

In addition, these medications may help to reduce the risk of developing other obesity-related health conditions such as fatty liver disease, sleep apnea, and joint problems

However, some early responders may notice subtle changes relatively quickly