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Source: Jastreboff, A

Prostacyclin analogs reverse excessive mitochondrial fission and cell proliferation phenotypes by inhibiting phosphorylation of the mitochondrial fission protein DRP1, revealing the impact of dynamic balance on immune-metabolic crosstalk ( mtDNA released from mitochondrial damage acts as a danger signal, which can activate the NLRP3 inflammasome, promote caspase-1-mediated cleavage of IL-1/IL-18 and macrophage recruitment

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Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis

[DOI] [PubMed] [Google Scholar] 31.Maselli D.B., Lee D., Bi D., Jirapinyo P., Thompson C.C., Donnangelo L.L., McGowan C.E

It plays several key roles: increasing insulin production, slowing down stomach emptying, and signaling to the brain that youre full