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Liver repair and regeneration exhibit several commonalities across different conditions, such as the activation of inflammatory and growth factor signaling pathways, including TNF-, IL-6, HGF, and EGF, which play crucial roles in hepatocyte proliferation and tissue repair

For most healthy individuals, this change is not harmful

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Moreover, mice with neutrophil-specific Gpx4 haploinsufficiency develop lupus phenotype and inhibition of neutrophil ferroptosis significantly mitigates disease development in lupus-prone mice