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Like Vaduganathan, he believes its largely because GLP-1 drugs lower excess fat in the body, which drives the disease

10.1038/4441022a Nature 19 LiY.MaoJ.ChaiG.ZhengR.LiuX.XieJ

Ferroptosis in drug resistance in cancer Despite significant advances in cancer treatment, drug resistance remains a major clinical challenge

In IR, the lipase-inhibiting activity of insulin decreases, and free fatty acids (FFAs) are released in large quantities, which disrupts mitochondrial function and induces toxic effects, leading to hepatocellular steatosis

Patients with severe cardiac, hepatic, or renal disease should also avoid testosterone injections, as exogenous androgens may exacerbate edema and other complications in these conditions