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The FDA has never approved this combination, and cardiology literature documents increased rates of arrhythmias and hypertensive episodes in patients attempting dual therapy

During the median follow-up period of 20 months (ranging from 6 to 48 months), the incidence of MACEs was significantly lower in the GLP-1RA group (7.63%)compared to the control group (19.85%) (HR 0.444

Persistent nausea, vomiting, or appetite suppression may lead a provider to hold a dose, extend the interval between increments, or cap the final dose below the maximum

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