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Second, the respective study populations were quite different, with STEP 1 including a younger, healthier population with more women (73.1% of the semaglutide arm in STEP 1 versus 27.7% in SELECT) and higher mean BMI (37.8 kg m 2 versus 33.3 kg m 2 , respectively) 14,21

The Swedish Heart Failure Registry: a living, ongoing quality assurance and research in heart failure

Dimensions: 5000 x 3750 px | 42.3 x 31.8 cm | 16.7 x 12.5 inches | 300dpi Date taken: 14 November 2016 Photographer: LAGUNA DESIGN/SCIENCE PHOTO LIBRARY

If tirzepatide has been exposed to temperatures above 86F (30C) or left unrefrigerated beyond 21 days, immediate action is necessary to ensure continued safe and effective diabetes or weight management

Lack of long-term safety data: Most peptides have not been tested in large-scale human studies

10.1016/j.bmc.2006.05.008 Bioorg