Prescription GLP-1 medications like semaglutide and tirzepatide demonstrated 1422% body weight loss in clinical trials
May be considered in challenging situations (e.g., renal dysfunction, pregnancy, drug interactions, possible nonadherence)
Decanoic acid is also a peroxisome proliferator activated receptor (PPAR) agonist, which elicits neuronal mitochondrial biogenesis (6466)
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GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis
Alternative pain management approaches may also be valuable, including topical NSAIDs (which have lower systemic absorption and reduced gastrointestinal risk), physical therapies, heat or cold application, and lifestyle modifications