Serious adverse effects, though rare, may include pancreatitis, diabetic retinopathy complications, hypoglycaemia when used with other glucose-lowering agents, cholelithiasis (gallstones), and dehydration or acute kidney injury associated with severe gastrointestinal symptoms
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In phase 2 trials, orforglipron achieved up to 14.7% mean weight reduction at 36 weeks in adults with obesity or overweight, in line with the mid-teens weight reduction from NVOs higher dose oral semaglutide , as well as the injectables currently in the market