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412 Notably, GLP-1RAs, including exendin-4, have been shown to attenuate microglial activation, resulting in a reduction in the expression of proinflammatory cytokines such as TNF- and IL-1

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These figures are similar to last years

GLP-1s were developed for blood sugar regulation in diabetes patients and curb appetite by mimicking the natural GLP-1 hormone found in the lower intestine, simulating insulin release from the pancreas in response to eating or drinking

Together, they create a holistic approach to weight and blood sugar management

Research in this area is ongoing