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Nonetheless, although mice with GIPR signal inhibition in the PNS do not show alterations in body weight and remain fully sensitive to weight loss induced by GIPR antagonism, these mice develop glucose intolerance with impaired glucose-induced secretion of insulin and GIP when fed a HFD

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GIP is also anti-emetic, reducing nausea-related behaviours triggered by a variety of agents, which has been attributed to Gipr -expressing cells in the brainstem/AP 13,14,15

Holman, M.A

Prausnitz MR, Langer R