Of the plethora of articles retrieved from the second MEDLINE search, we identified 28 systematic reviews of animal stud-ies, [39-41] GSH-related genetic polymorphisms linked to various cancers (colorectal can-cer, [42] leukaemia, [43,44] lung cancer,[ 45,46] bladder cancer, [47] gastric cancer, [48,49] prostate cancer, [50-53] adult brain tumours, [54] basal cell carcinoma [55] ) and linked to other disorders (autism, [12, 13] hypertension, 56,57 respiratory diseases, [58,59] cataract, [60] myelodysplastic syndrome, [61,62] glioma [63] and male idio-pathic infertility.[ 64] ) There were 9 RCTs identified from two systematic reviews of the use of GSH to reduce chemotherapy-induced toxicity (6 cisplatin, 2 axaliplatin, 1 platinum)
First, it increases collagen, elastin, and glycosaminoglycan synthesis
Site rotation importance Repeatedly injecting in the same location can cause local tissue changes including lipohypertrophy (abnormal fat accumulation) or lipoatrophy (fat loss creating depressions)
doi: 10.2165/00003495-198121040-00001
It can regulate the production of MMPs, such as MMP-1 and MMP-3, by fibroblasts (31)
Fact: Injections can be risky and are not recommended by experts
