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10.1016/j.jnutbio.2014.07.003 81 KontoghiorghesG

Professional Supervision: Injections are provided in a medically guided setting

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The IGF-1 axis benefits from the same pause: it drifts back toward baseline instead of sitting chronically elevated, which is the safer position given GH/IGF-1s growth-promoting signaling

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[6] Injecting sermorelin 30 to 60 minutes before the child falls asleep allows the drug to reach peak plasma concentration (Tmax approximately 10 to 20 minutes after subcutaneous injection) just before the natural GH pulse window