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La actividad fsica, especialmente el ejercicio aerbico moderado a vigoroso, ha demostrado mejorar la sensibilidad a la insulina y el control metablico general
Methods Mol Biol 1817:157168
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Mechanistically, by inhibiting HDAC activity, these agents augment histone acetylation levels (specifically H3 and H4), thereby activating the transcription of cardioprotective genes, including those regulating anti-apoptotic and antioxidant processes 152,155