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1e were suggested for slow thermodynamic thiol-disulfide equilibrations between different glutaredoxins, GSH, and the metal-binding domains of the proteins HMA4 and Atox1 60

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Pharmacokinetic drug interaction studies with JANUMET have not been performed

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The trial also demonstrated superiority to placebo for all confirmatory secondary outcomes assessed, including pain-free walking distance at week 52, health-related quality of life (Vascular Quality of Life Questionnaire-6) at week 52, and maximum walking distance at week 57