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10.3390/molecules28207122 56 LiuH.HuangY.HuangM.WangM.MingY.ChenW.et al (2023b)

Study 3: Combination With Diet Independent work showed that NNMT inhibition plus a lean/low-fat diet accelerated weight and fat loss beyond diet alone, improved the lean-mass-to-body-weight ratio, and ameliorated obesity-linked liver pathologies

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All these effects appear to be primarily mediated by Auranofin, as no significant histological difference was observed between the Auranofin and combination groups, indicating that the effect of Auranofin is not hindered by the combination with COJEC in vivo