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Weight loss of 10% or more may necessitate levothyroxine dose adjustments, and patients should be educated to recognise symptoms of both hypothyroidism (fatigue, cold intolerance, constipation) and hyperthyroidism (palpitations, anxiety, tremor) that might indicate the need for dose modification

This means semaglutide might make it tricky to travel for several days or to work for long hours without breaks

"The biggest problem with GLP-1 drugs is that they have to be injected once a week, and they can induce a very strong feeling of nausea," said Kumar