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Combining both types of agents may yield additional benefits: in a recent observational propensity-matched study from 3 US claims databases of 12,854 patients with type 2 diabetes who added an SGLT2i or sulfonylurea to baseline GLP-1 RA treatment, adding an SGLT2i produced greater cardiovascular benefit (comprising MI, stroke, all-cause mortality, and HHF) [17]

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In clinical trials, nausea (12-22%), diarrhea (12-16%), vomiting (5-9%), constipation (6-7%), abdominal pain (6-9%), and dyspepsia (7-10%) were frequently reported

Insurance coverage can also determine what medication option is available to you

The first ten days were uneventful aside from mild nausea around day three or four

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