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2 Encouraging Diabetes Outcomes In the VESPER-2 study involving obesity and type 2 diabetes: Up to 2.2% HbA1c reduction with 1.6 mg weekly berobenatide Dose-dependent reductions in both body weight and glucose levels Continued favorable tolerability profile The combination of meaningful weight loss and glycemic control positions berobenatide as a potential cardiometabolic therapy

Free radicals are unstable molecules that can damage cells, leading to inflammation and oxidative stress

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Zhou et al., 2025) (Figure 8C)

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Additionally, the cyclic trisulfide structure of LASSS, as opposed to the linear trisulfides such as GSSSG and cysteine trisulfide (Cys-SSS-Cys), could guarantee the unique reactivity of LASSS (see again Figure 1a for chemical structures)