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Experimental design For this study, we performed two experiments for different purposes

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Outcome Primary: Cardiovascular outcomes - major adverse cardiovascular events [MACE]

No, no, no

It typically has the most consistent subcutaneous fat layer, which means absorption is reliable and predictable

Thus, the clinical benefits for the risk of heart failure and kidney outcomes, except albuminuria, are likely to be a strength of SGLT2is, whereas those for the risk of stroke are a strength of GLP-1RAs (Graphical Abstract)