This triggers the gastrocolic reflex, a natural response where stomach filling signals the colon to make room by initiating a bowel movement
These drugs by increasing insulin secretion and possibly, beta cell mass, decrease plasma glucose and lipids and have a secondary action to reduce food intake and bring about weight loss
21 Mechanistically, the presence of GLP-1 receptors in the retina raises the possibility of a direct toxic effect of the GLP-1/GIP agonists leading to the observed retinopathy progression
As a rough framework, expect one to two pounds of weight loss per week once you reach your target dose
Higgins JPT, Li T, Deeks JJ (editors)
First approved to treat type 2 diabetes, GLP-1 based drugs are now used to aid weight loss in obesity and to help lower the risk of heart failure and treat obstructive sleep apnea, a common breathing-related sleep disorder, in people with obesity