The five genes CHKA, EBP, RPS6KA5, NCSTN, and CHRM3 were not used alone to generate the reported AUC of 0.923
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International Journal of Oncology , 20(1):69-75 Vogel, J
This speed reflects the same accelerated turnover causing the purging in the first place
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Additionally, various difficult toxicities associated with MTX such as testicular toxicity, which is regarded as a severe adverse effect that may result in infertility, may limit the drugs therapeutic impact (Howard et al
