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This is particularly relevant for medications with narrow therapeutic indices or those requiring rapid absorption

Norwood, J

Peptide molecules at this interface experience mechanical stress that can cause denaturation, essentially unfolding the protein structure and reducing biological activity

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But the study warns the drugs may also cause muscle loss, which is essential for strength, posture, and long-term health

However, the Work Group agreed that a short-term trial of L-carnitine (3 to 4 months) was reasonable in selected patients to enhance muscle strength and exercise capacity, in light of its favorable side effect profile, lack of alternative effective therapies, and benefits shown in several studies