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GHK-Cu supports tissue repair and regeneration, helping acne lesions heal faster while minimising the risk of scarring

Other: pregnancy and lactation (low cobalamin levels found in the third trimester may be physiological) genetic disorders and infection

Studies involving patients with severe organic diseases (e.g., cancer, chronic kidney disease) to avoid confounding effects of underlying conditions on inflammation or depression outcomes

Treatment of vitamin B12 deficiency is likely to last only 4 6 weeks

Lutsenko S, Roy S, Tsvetkov P (2025) Mammalian copper homeostasis: physiological roles and molecular mechanisms

NNMT and lipid accumulation: in cell studies, reducing NNMT was associated with less stored fat