In some embodiments, Sodium Thiosulfate, Potassium Thiosulfate, HMTBa, Oltipraz, D-cysteine, D-methionine, or a combination thereof improves spiral ganglion neuron survival, function, viability, health, growth, or a combination thereof following chemotherapy-induced ototoxicity by at least or about 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or more than 95%
Neither requires intramuscular delivery
Moreover, concentrations of circulating endotoxin and the number of bacteria in the intestinal lymph nodes and the lymphatic circulation also correlate with disease severity [80]
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Ono-Iwashita, Y., Oshima, T., & Imahori, K
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