tirzepatide better than retatrutide vs #tirzepatide at a glance… #onthepen I'm getting asked about Retatrutide

Despite its promise as a transformative solution to obesity, retatrutide is still in the investigational stages

This has been demonstrated in human peripheral blood mononuclear cells, where exenatide blocked NF-kB binding to DNA and downregulated both TNF and IL-1 beta expression

doi: 10.1093/jpp/rgaf124 58

Nevertheless, translating these laboratory findings to clinical joint pain relief in humans requires further investigation

This does not necessarily mean their product is inferior

Specifically, the aromatic ring of Phe22 forms pi-stacking interactions with Tyr36 on the GIPR ECD, while the bulky -methyl group of MeL13 perfectly fills a hydrophobic crevice located near Arg131, anchoring the molecule firmly in the pocket despite the lack of a salt bridge