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Participants who completed VESPER-1 were eligible to enroll in an exploratory open-label extension that evaluated higher weekly dosing (1.6 mg, 2.4 mg) and less frequent dosing (every other week and monthly)

The GSH-responsive AP probe-net blocks the APE1 activity, thereby inducing cell death

FDA prescribing information for some GLP-1 receptor agonists (particularly those approved for weight management) includes recommendations to monitor heart rate at regular intervals and consider discontinuation for sustained increases in resting heart rate