In healthy mitochondria, SIRT3 interacts with ATP5O, while the low pH owing to the loss of membrane potential weakens the binding affinity between SIRT3 and ATP5O, leading to the redistribution of SIRT3 to other mitochondria substrates
These results are in line with previous findings indicating that inhibition of mitochondrial complex I synergizes with mitochondrial antioxidants in impairing cancer cell fitness, supporting the notion that complex I is a dominant determinant of viability (28)
| | Extended Low-Dose Research | 5mg subcutaneous, 3x/week | 50mg oral, daily | MOTS-c AM fasted
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