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With insulin resistance, common in people with excess adiposity, prediabetes, and type 2 diabetes, glucagon and insulin levels may be elevated

Occasional minor cramps during dose escalation can be normal

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Safety and pharmacokinetics of single and multiple ascending doses of the novel oral human GLP-1 analogue, oral semaglutide, in healthy subjects and subjects with type 2 diabetes

They come from different populations, different treatment durations, different placebo runs, and different statistical estimands (for example, the efficacy estimand that assumes continued treatment versus the treatment-regimen estimand that counts discontinuations)

The study was conducted over a one year period