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This can be particularly helpful for older adults who, due to age-related changes, dont produce as much sweat as younger people in warmer weather

If you move forward with this approach and side effects do occur, your physician can help you manage them

Most side effects during the first few weeks are gastrointestinal: nausea, constipation, reduced appetite, and occasionally diarrhea

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These conformational changes are stabilized by additional noncovalent interactions involving the conserved residues, such as the Arg121 making hydrogen bonds with Asp67 to further strengthen the pi-cation interactions involving Trp72, Arg102, and Trp110 (see Figure 4 inset 2)