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#Pharmacy #DrugInteractions #BNF2025 #ClinicalPharmacology #Pharmacist #Methotrexate #NSAIDs #PatientSafety To view or add a comment, sign in Day 118 of #RISEChallenge Drug of the Day: Prucalopride Drug Name: Prucalopride Class: Selective 5-HT receptor agonist Mechanism of Action: Prucalopride stimulates serotonin (5-HT) receptors in the gastrointestinal tract, enhancing colonic peristalsis and promoting bowel movement

Targeting glutamine metabolic reprogramming of SLC7A5 enhances the efficacy of anti-PD-1 in triple-negative breast cancer

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GI-Mucosal Repair and Leaky Gut Prevention Leaky gut describes a state of increased intestinal permeability where tight junction proteins loosen, allowing toxins and bacteria into circulation

It has been shown to: Stimulate collagen and elastin production

Inhibiting the elevated expression of GJ components in hepsin / mice reduces APAP toxicity by limiting oxidative stress in the liver To investigate GJ expression variations after APAP administration in wild-type and hepsin / mice, immunofluorescence staining for Cx32 was assessed at different time points