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This counterintuitive pharmacology has been confirmed in vivo whereby the administration of the FXR agonist GW4064 by mouth drives hyperglycaemia and obesity (349) while intraperitoneal injection exerts protection from it (350)
The salivary glands of gila monsters produce a GLP-1 peptide that does not have a DPP-4-recognized site leading to the first therapeutic incretin, exenatide - a twice daily subcutaneous injection [25]
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Examining Motivation & Good Questions
We also highlighted the growing opportunity to identify type 1 diabetes at an early stage through autoantibody screening - and the important work of the EDENT1FI project, which is screening thousands of children across Europe for early-stage T1D
Understanding the right dosage is vital
