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Dutasteride (brand name Avodart) is a 5-alpha reductase inhibitor originally approved by the FDA for benign prostatic hyperplasia, an enlarged prostate condition

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Nevertheless, several cellular studies have suggested the protective roles of chemical anti-oxidants, such as GSH, as well as drug metabolizing enzymes, such as NQO1 and UDP-glucuronosyltransferases (UGTs), against AQ-induced cytotoxicity (Tafazoli and OBrien, 2009

Several preclinical studies have tested the efficacy of VGSC-inhibiting drugs on cancer cells (327, 328)