DEM has been described as an excellent activator of the Nrf2 pathway in the HepG2 model (Bischoff et al
First-line treatments include PDE5 inhibitors (sildenafil, tadalafil, vardenafil, avanafil), which are effective in approximately 70% of men
INGREDIENTS: Deionized Water, Lecithin Phospholipids, L-Glutathione, Alcohol (ethanol), Xanthan Gum, Potassium Hydroxide (for pH adjustment)
Moore EM, Wagner C, Komarnytsky S
59(Suppl 5): 87-94
RNA-seq and transcriptomic analysis revealed that Auranofin and the combination with COJEC significantly downregulated pathways associated with tumor malignancy and metastatic capacity, such as MTORC1 signaling, glycolysis, Notch signaling, KRAS signaling, WNT- catenin signaling, hypoxia, angiogenesis, IL-6/JAK/STAT3 signaling, and epithelial-to-mesenchymal transition (Fig