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The APOE4 allele, which is present in approximately 10-15% of people, increases the risk of developing Alzheimer's disease and lowers the age of onset

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SARS-CoV-2 spike protein impairs endothelial function via downregulation of ACE 2

When the body, especially after repeated administration, recognizes the originally inert PEG chains as foreign substances, specific anti-PEG antibodies will be produced [216]

Biomarkers like malondialdehyde, 8-hydroxydeoxyguanosine, or plasma antioxidant capacity can contextualize oxidative stress, though these tests remain research-grade in many settings